Sex-specific effects of appetite suppressants on stereotypy in rats
Fig 5
t-distributed Stochastic Neighbor Embedding (t-SNE) and hierarchical clustering analysis delineate distinct clusters of drug-induced motor effects in rats, with tesofensine in females demonstrating an intermediate profile.
The analysis reveals two primary clusters: one encompassing amphetamine-like drugs associated with stereotyped behaviors and another comprising drugs that do not elicit such behaviors. t-SNE map illustrating the clustering of motor effects across various treatments. Each data point represents an individual subject, with triangles indicating males and circles indicating females. Colors denote different treatments: saline (pink), phentermine (yellow), mazindol (light green), diethylpropion (beige), cathine (blue), tesofensine (burgundy), and 5-HTP (dark green). Tesofensine-treated females (burgundy circles) are positioned intermediately between the two main clusters. This suggests that tesofensine in females elicits a motor effect profile that shares characteristics with both amphetamine-like and non-stereotypy-inducing drugs.