Impact of cardiosphere-derived cells on the maladapted right ventricular muscle in a rat sugen/hypoxia model of pulmonary hypertension with right ventricular dysfunction
Fig 5
Cardiomyocyte hypertrophy assessment of the rodent RV free wall at 4 weeks post treatment.
(A) Representative images of cardiomyocyte cross-sections within the RV free wall of PBS- or CDC-treated PAH animals are shown. The cell membranes are shown in green, and the myofibrils are shown in red. Scale bar = 100um. (B) Analysis of the mean cross-sectional areas of cardiomyocytes (± SEM) from the different PAH treatment groups are shown. (C) Hypertrophy-associated protein expression is represented by individual boxes with the cyan (PAH-PBS vs. Healthy) and orange (PAH-CDC vs. PAH-PBS) bars visually indicating up or down regulation across a central horizontal axis. (D) Table lists the fold changes (log2(FC)) of proteins for the relevant samples. Darker purple colors (- numbers) represent downregulation and lighter pink colors (+ numbers) represent up-regulation of proteins. Values denoted by * represent proteins that were identified only in certain samples (only in CDC-treated or only in control sample), therefore may not be indicative of true changes.