The neuronal chaperone proSAAS is highly expressed in the retina
Fig 2
ProSAAS is expressed in multiple cell types in the human and rodent retina. proSAAS transcript expression in retinal cell types of: Panels A-C: Human; Panels D-F: Mouse.
Panels A, B: Differential cell expression plots. Panels B-C and E-F: UMAP projections and differential cell expression plots. Specific cell types are indicated by arrows in panels B and E, and by color in panels C and F. Relative proSAAS transcript expression is greatest in horizontal cells in both species, followed by RGCs. RGC subgroup expression is identifiable in the mouse data (seen as orange in panel F). Amacrine cell interneurons are subdivided into different types in the human study (panel A), and as a single cell type in the mouse study (panel D). Panel G depicts a comparison of relative Pcsk1n mRNA expression in different RGC subtypes [data from [24,30]], while Panel H shows a comparison of changes in retinal PCSK1N expression in five disorders affecting the retina.