Photobiomodulation therapy increases neural stem cell pool in aged 3xTg-AD mice
Fig 6
Intracellular tau hyperphosphorylation in the hippocampus is not significantly altered by PBM treatment in aged 3xTg-AD mice.
A. Representative images of hippocampal sections showing extensive intracellular accumulation of pTau (AT8, red; BIII-tubulin, green; DAPI, blue). (Scale bar = 200µm) B. Regional quantifications of AT8+ cells show significant accumulation of intracellular pTau throughout the hippocampus of 3xTg-AD mice with no apparent effect of PBM treatment (One-way ANOVA. *p<0.05, **p<0.01, ***p<0.001).