Depth-dependent contributions of various vascular zones to cerebral autoregulation and functional hyperemia: An in-silico analysis
Fig 9
(a) Design principles of the proposed cerebrovascular model.
Solid arrows represent the successive steps taken to derive HVTFs, with a primary focus on deriving WT-MT transfer functions. Dashed arrows indicate potential future enhancements, such as incorporating WSS-MT transfer functions and adding physiological details like delays in WT/WSS-MT relationships. (b) Applications of the proposed cerebrovascular model. This diagram illustrates how the model can be used for in-silico analysis of other core functionalities of the CBF regulatory system, including vasomotion and functional hyperemia, as well as for studying pathological conditions associated with dysfunctions in these mechanisms.