Prediction of protein interactions with function in protein (de-)phosphorylation
Fig 1
Structure of the work presented in this manuscript.
Left: computational prediction of PTM-related directed protein interactions (PTM-PPIs). A random forest model was constructed to predict PTM-PPIs based on hyperbolic topological features and network properties extracted from the hPIN. Right: quantitative proteomics data revealed dysregulated proteins in a cellular model of SCA1. The results were interpreted using predicted PTM-PPIs, providing directions for future experimental research on SCA1 pathogenesis.