Home cage-based insights into motor learning and strategy adaptation in a Huntington disease mouse model
Fig 5
Analysis of movement jerkiness.
(A) Two example traces that illustrate a smooth (top) versus jerky (bottom) lever pull trajectory (black traces) with the corresponding 10Hz high-pass filtered trajectories superimposed (orange traces). The standard deviation (Std) of these high-pass filtered trajectories quantitatively captures the movement’s jerkiness. (B) The daily averages of Std for the high-pass filtered trajectories across WT and zQ175 mice further reveals significant differences in movement jerkiness, with zQ175 mice consistently exhibiting higher levels of jerkiness compared to WT mice, a difference that becomes more pronounced later in the testing period as average hold times increase (RM two-way ANOVA, genotype p = 0.017 F(1, 22) = 6.576, days p = 0.463 F(8.019, 176.4) = 0.9676, interaction p < 0.0001 F(57, 1254) = 2.762). Data presented as mean ± SEM.