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Integration of pharmacodynamics, network pharmacology and metabolomics to elucidate the effect and mechanism of Jingfang Granule in the treatment of Paraquat induced Pulmonary fibrosis

Fig 5

The expression of Bcl-2, Bax, Caspase-3, p-ERK1/2, p-PI3k and p-Akt in pulmonary tissues recorded by western blot.

(A) The expression of Bcl-2, Bax, Caspase-3, ERK1/2, p-ERK1/2, PI3k, p-PI3k, Akt and p-Akt in pulmonary tissues recorded by western blot. (B) Quantitative result of Bcl-2, Bax, Caspase-3. (C) Quantitative result of p-ERK1/2, p-PI3k and p-Akt. Data reported in the figures are mean ± SD, PQ group compare with the normal group, ##P < 0.01 or #P < 0.05; JF group compare with the PQ group, **P < 0.01 or * P < 0.05.

Fig 5

doi: https://doi.org/10.1371/journal.pone.0318246.g005