Inhibition of CFTR-mediated intestinal chloride secretion by nornidulin: Cellular mechanisms and anti-secretory efficacy in human intestinal epithelial cells and human colonoids
Fig 5
The effect of nornidulin on intracellular cAMP level.
The experiment involved pretreating T84 cells for one hour with different conditions: vehicle (control), nornidulin, N9 (5 μM), nornidulin (5 μM) with FSK (5 μM), or FSK (5 μM). Following treatment, intracellular cAMP levels were determined using a cAMP assay kit. The results are expressed as cAMP concentrations with standard deviation (S.D.) (n = 5–6). ns, not significantly different from the control group. **, p <0.01 compared to the indicated group. ****, p <0.0001 compared to the indicated group.