Diffuse white matter pathology in multiple sclerosis during treatment with dimethyl fumarate—An observational study of changes in normal-appearing white matter using proton magnetic resonance spectroscopy
Fig 5
Correlation between ratios of metabolite concentrations versus disease duration.
Correlation plots showing ratios of 1H-MRS metabolite concentrations of mIns and tNA versus disease duration (a) and tNA and tCr versus disease duration (b). n = 18 because of lack of data in one patient (insidious disease start of progressive MS with radiologic disease activity). r and p refer to Spearman correlation coefficients. p < 0.05 is considered statistically significant. Lines indicate simple linear regression fit with 95% confidence interval. tNA, total N-acetylaspartate and N-acetylaspartylglutamate; mIns, myo-inositol.