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New antibacterial candidates against Acinetobacter baumannii discovered by in silico-driven chemogenomics repurposing

Fig 1

Computational chemogenomic analyses.

(A) Workflow diagram showing the computational steps and the number of drugs screened in each step. (B) Venn Diagram. Clusters generated by comparative analysis between therapeutic targets deriving from DrugBank (510 clusters comprising 1,402 orthologs) and Therapeutic Target (TTD) (192 clusters comprising 676 orthologs) databases and proteins deriving from Acinetobacter baumannii. (C) Therapeutic recommendation of 31 predicted drugs based on computational analysis.

Fig 1

doi: https://doi.org/10.1371/journal.pone.0307913.g001