Differences in sensory nerve block between levobupivacaine and bupivacaine at low concentrations in humans and animals
Fig 5
Bupivacaine suppressed the spiking response of wide-dynamic-range neurons to innocuous stimuli more potently than levobupivacaine in anesthetized rats.
(A) Typical responses of wide-dynamic-range (WDR) neurons to innocuous stimuli (brush and 4 g von Frey hair) at baseline and after subcutaneous injection of bupivacaine and levobupivacaine (A). (B) Values represent the median percent change in spiking responses to innocuous stimuli following subcutaneous administration of bupivacaine (n = 5), levobupivacaine (n = 5), or saline (n = 3) compared with measurements taken before drug administration (baseline). The suppression of firing was stronger after administration of bupivacaine. The baseline responses of different groups were analyzed using Friedman and Dunn’s post hoc tests. The Mann–Whitney U test assessed between-group differences in anesthesia-induced changes. A significant difference was identified when the FDR-adjusted p-value from the Mann–Whitney U test was < 0.05. #: significant differences vs. baseline. *: significant differences between bupivacaine and levobupivacaine.