Starve a cold or feed a fever? Identifying cellular metabolic changes following infection and exposure to SARS-CoV-2
Fig 5
Global metabolite profiling of SARS-CoV-2 inoculated A549 cells.
Similar to ACE2-A549 cells, metabolite profiles from A549 cells were compared by (A) PCA and (B) PLSDA. (C) Heatmap analysis of significant metabolites (n = 377) reveals a different temporal phenotype in cells that are exposed to SARS-CoV-2 but remain uninfected. Mean intensities of each metabolite were clustered into 3 groups: 0 hpi (n = 6), 6 hpi (n = 6), and 16 hpi (n = 6). Normalized fold change of specific metabolites is relative to peak concentration across 0, 6, and 16 hpi.