Vorolanib, sunitinib, and axitinib: A comparative study of vascular endothelial growth factor receptor inhibitors and their anti-angiogenic effects
Fig 6
Computer modeling of vorolanib bound to VEGFRs.
(A) VEGFR1; (B) VEGFR2; and (C) VEGFR3. Left panels, protein displayed using ribbons while the protein surface is displayed using a white transparent pattern. Vorolanib is shown as a purple stick image and image is at 50 ns stimulation. Left and center panels, binding of vorolanib with VEGFR at 50 ns stimulation. Center panels, 3D diagrams of interaction with hydrogen bonds indicated by yellow dotted lines and π-π stacking is indicated by green dotted lines. Right panels, 2D diagrams depicting the interaction of vorolanib with VEGFRs. Hydrogen bonds are indicated using purple arrows, and π-π stacking is indicated with a green line. VEGFR, vascular endothelial growth factor receptor.