Vorolanib, sunitinib, and axitinib: A comparative study of vascular endothelial growth factor receptor inhibitors and their anti-angiogenic effects
Fig 2
Kinase assay screen using 10μM of each TKI.
(A) Control (baseline) TREEspot image depicting what 100% inhibition of all receptors associated with angiogenesis (blue) would look like. TIE2 receptor signaling is essential to maintain blood vessel stability and 100% inhibition of the TIE2 receptor is depicted (red). (B) In comparison to anti-VEGF antibodies, the three tested TKIs effectively inhibit all the receptors involved in pathological angiogenesis; the TKIs differ from each other as axitinib strongly inhibits TIE2, which is undesirable as maintained TIE2 function is essential for vascular stability. TKI, tyrosine kinase inhibitor; VEGF, vascular endothelial growth factor.