The impact of apolipoprotein E, type ∊4 allele on Alzheimer’s disease pathological biomarkers: a comprehensive post-mortem pilot-analysis
Fig 5
Grey matter NeuN number over the progression of Tau phosphorylation and Aβ aggregation, and their associations with ApoE4 and cognitive status.
(A) Total number of NeuN’s progression in correlation with Braak stages. (B) The association between Ripa immunoassay of p-tau level and the total number of NeuN under different sex groups. (C) The association between Guhcl protein precipitation of p-Tau level and the total number of NeuN different sex groups. (D) The total number of NeuN’s progression is in correlation with the Thal stages. (E) The association between Ripa immunoassay of Aβ42 level and the total number of NeuN in different sex groups. (F) The association between Guhcl protein precipitation of Aβ42 level and the total number of NeuN in different sex groups. (G) ApoE4 and Cognitive status influences on NeuN cell aggregation under different sex groups. Pearson’s R correlation was conducted B-C, and E-F. Two-way ANOVA and Tukey’s HSD post-hoc analysis was used for G. Data represent mean ± SEM. * p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001.