VDX-111 targets proliferative pathways in canine cancer cell lines
Fig 5
Pathway analysis of gene expression correlating with VDX-111 survival.
(A) Pathway analysis using Metascape (metascape.org) with an input of 1261 significantly correlated genes (p<0.05) including either a positive or negative correlation with 1 μM treatment. Multiple signaling pathways were identified among the significantly correlated genes. (B) Heatmap of expression levels in each cell line of genes in the Metascape analysis of the PI3K-AKT pathway. Cell lines with >50% survival at 1 μM treatment are indicated as resistant, <50% survival at 1 μM treatment are indicated as sensitive.