Vitamin D regulates COVID-19 associated severity by suppressing the NLRP3 inflammasome pathway
Fig 5
Graphical illustration of main findings of the study.
The NLRP3 inflammasome pathway and associated hyperinflammation markers as determined by IL-1β, IL-6, IL-17 and D-Dimer are attenuated upon VitD3 treatment in severe COVID-19 patients. This is associated with an enhancement of the anti-viral immune response as detected by the ability of VitD3 to enhance RIG-1/MDA-5 and JAK-STAT signaling pathways along with the production of ISGs like MX-1 and ISG-15.