Exploring the potential of bis(thiazol-5-yl)phenylmethane derivatives as novel candidates against genetically defined multidrug-resistant Staphylococcus aureus
Fig 5
Compounds 23a and 28b shares overlapping positions with UDP-N-acetyl-alpha-D-muramate binding pocket in S. aureus MurC.
Panel A shows the docking poses for UDP-N-acetyl-alpha-D-muramate (green), 23a (blue), and 28b (yellow) into MurC. Panel B demonstrates 2D maps of H-bonds and hydrophobic interactions of UDP-N-acetyl-alpha-D-muramate with MurC amno acid residues. Van der Waals, Pi–cation, Pi–donor hydrogen bond, alkyl and Pi–alkyl are considered hydrophobic interactions.