Exploring the potential of bis(thiazol-5-yl)phenylmethane derivatives as novel candidates against genetically defined multidrug-resistant Staphylococcus aureus
Fig 1
In vitro antimicrobial activity of bis(thiazol-5-yl)phenylmethane derivatives 10–31 and control antimicrobial compounds at a concentration of 100 μM against selected multidrug-resistant bacterial strains.
Bacterial strains were exposed to compounds and control antimicrobial drugs at a fixed concentration of 100 μM for 18 hours. Subsequently, resazurin (25 μM) was added, and the plates were further incubated for 3 hours. Following incubation, the optical density at 700 nm (OD700 nm) was measured, and the post-treatment viability percentage was normalized to the untreated control (UC). AZT-aztreonam, COL-colistin, FOX-cefoxitin, MEM-meropenem, OX-oxacillin, VAN-vancomycin. The data presented in the figure represents the mean ± standard deviation (SD) from three independent experimental replicates.