Thiophene derivative inflicts cytotoxicity via an intrinsic apoptotic pathway on human acute lymphoblastic leukemia cells
Fig 5
F8 induces caspase activation.
Compound F8 CC50 and 2X CC50 (2.89 μM and 5.78 μM) induced significant caspase 3/7 activation in CEM cells. The cells were incubated for 8 h and stained with NucView 488 caspase-3/7 substrate. Statistical analyses were obtained using the two-tailed Student’s paired t-test compared to the vehicle control (1% DMSO).