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Analytical sameness methodology for the evaluation of structural, physicochemical, and biological characteristics of Armlupeg: A pegfilgrastim biosimilar case study

Fig 5

Comparison of product-related impurities.

(A) SE-HPLC chromatograms analyzing size variants, (B) SEC-MALS chromatograms analyzing size variants, (C) CEX-HPLC chromatograms analyzing charge variants, (D) RP-HPLC chromatograms analyzing impurities.

Fig 5

doi: https://doi.org/10.1371/journal.pone.0289745.g005