Lansoprazole protects hepatic cells against cisplatin-induced oxidative stress through the p38 MAPK/ARE/Nrf2 pathway
Fig 7
Lansoprazole activates the p38 MAPK/Nrf2/ARE pathway and suppresses cisplatin-induced cell death in RL34 cells.
Schematic model of the Nrf2-dependent cytoprotective signaling pathway by lansoprazole in RL34 cells. Lansoprazole suppresses cisplatin-induced cytotoxicity through the activation of the Nrf2 pathway, accompanied by induction of antioxidant genes such as that encoding HO1. These effects are dependent on the p38 MAPK pathway.