IL-17 cytokines preferentially act on naïve CD4+ T cells with the IL-17AF heterodimer inducing the greatest functional changes
Fig 5
Pathway induction following IL-17 exposure.
A. Overlapping and unique upregulated canonical pathway enrichment in bulk CD4+CD25- T-cells in IL-17A, IL-17F, and IL-17AF conditions compared to media-only cells. B. Bar chart of significantly (p < 0.05) altered in at least two of three conditions. C. Z-score of significantly enriched canonical pathways with non-unique pathways colored in grey. Top increased unique pathways labeled.