The effect of a novel AQP4 facilitator, TGN-073, on glymphatic transport captured by diffusion MRI and DCE-MRI
Fig 4
Averaged time activity curves (TAC) of three different regions of rats’ brains.
The percentage signal change is plotted as a function of time for theTGN-073 treated (n = 6, blue circles), vehicles (n = 6, orange circles), and artificial CSF (n = 3, grey circles) in (a) prefrontal cortex, (b) cerebellum and (c) whole brain. Pink shading on graphs indicates the period of tracer infusion. Shading on the anatomical images of the brain illustrates the location of ROIs, blue: prefrontal cortex, purple: cerebellum and orange: whole brain.