The effect of a novel AQP4 facilitator, TGN-073, on glymphatic transport captured by diffusion MRI and DCE-MRI
Fig 3
Serial MRI images in the sagittal plane of a rat’s brain.
Using Gd-DTPA as the paramagnetic contrast agent reveals glymphatic transport with higher uptake and more parenchymal penetration over the whole brain over a period of two hours in the animals treated with the AQP4 facilitator (TGN-073) compared to vehicle-only treated rats. The time (in minutes) shows the change over time from starting the Gd-DTPA infusion.