The combination of chronic stress and smoke exacerbated depression-like changes and lung cancer factor expression in A/J mice: Involve inflammation and BDNF dysfunction
Fig 5
CUMS, smoke or their combination increased pro-inflammatory cytokines production, but decreased peripheral mononuclear cells viability after stimulated by LPS or ConA.
The concentration of inflammatory factors in the lung were detected by ELISA kits, while the spleen mononuclear viability was measured by MTT method. (A-F) The concentrations of IL-1, IL-2, IL-6, IL-8, IL-10 and IL-12. (G and H) The viability of peripheral mononuclear cells. The data are expressed as mean ± SEM (n = 9–10) **P < 0.01 versus control group; ##P < 0.01 versus stress group; ^P < 0.05 versus smoke group.