Synergistic drug combinations designed to fully suppress SARS-CoV-2 in the lung of COVID-19 patients
Fig 5
Mechanism of synergy between RDV and AZI.
RDV and AZI synergize both at entry and post-entry level, synergy being optimal with continuous treatment. (A) Drugs were added only at the time of infection; (B) Drugs were added only after infection; (C) Drugs were added throughout the experiment. In all cases Vero E6 cells were seeded at Day 0, infection was performed at Day 1 and readout was measured at Day 4. The results of the Mac Synergy II, Synergy Plot 99.9% analyses are shown in the right part of each panel. Tx = treatment.