The relationship of mRNA with protein expression in CD8+ T cells associates with gene class and gene characteristics
Fig 2
Gene class-specific mRNA and protein abundance.
(A) Integrated mRNA (TPM) and protein abundance (CN) of secreted proteins, CD molecules, transcription factors, RNA-binding proteins (RBPs), mammalian (light green) and mitochondrial (dark green) ribosomal proteins, and TCA (citric acid) cycle proteins of activated CD8+ T cells (TActivated). The number of genes per class, the Pearson’s correlation coefficient, and regression line (linear model) were calculated for each class and are indicated in the panels. The correlation was performed independently for mammalian (light green) and mitochondrial (dark green) ribosomal proteins. (B, C) Pearson’s correlation coefficient (B) and mRNA-to-protein slope (also known as Beta-coefficient) (C) of the integrated mRNA and protein abundance of gene classes indicated in (A) during T cell differentiation and upon T cell activation. “*” indicates correlation and regression with p-value <0.05.