CCT196969 effectively inhibits growth and survival of melanoma brain metastasis cells
Fig 6
CCT196969 downregulates expression of STAT3, p-STAT3, p-MEK and p-ERK in MBM cell lines.
(A) Western blots from H1 and H3 cells, untreated or treated with selected doses of CCT196969; 1, 2 and 4 μM. (B) Quantification of Western blots normalised against the loading control GAPDH and in ratio with the untreated control. The experiments were done in triplicates. The graphs show the mean with SEM. Abbreviations: ns: not significant, *: p < 0.05, **: p < 0.01, ***: p < 0.001, ****: p < 0.0001.