CCT196969 effectively inhibits growth and survival of melanoma brain metastasis cells
Fig 1
CCT196969 treatment reduces viability in MBM cell lines in a dose-dependent manner.
(A) Representative microscopic images (20x objective) of H1, H2 and H3 cells grown in monolayers, exposed to increasing concentrations of CCT196969; untreated, 0.5, 1.0 and 4 μM, for 72 h. Scale bar = 100 μm. (B) Representative viability curves of the cell lines grown as monolayers, exposed to increasing concentrations of CCT196969. The mean IC50 dose value for CCT196969 was calculated from the experimental triplicate and is presented in the graph.