Sex-, age-, and organ-dependent improvement of bile acid hydrophobicity by ursodeoxycholic acid treatment: A study using a mouse model with human-like bile acid composition
Fig 3
Effects of UDCA treatment on BA pool and fecal BA excretion.
DKO mice at 20 weeks of age, with (+) or without (-) UDCA treatment, were compared. (A) Composition of BAs in the total BA pool and feces. The total BA pool in the enterohepatic circulation was calculated by adding total BAs in the liver, gallbladder, and small intestine. The broken line indicates the boundary between conjugated and unconjugated BAs. (B) BA amounts in the total pool and feces. Each column and error bar represents the mean and SEM. *P < 0.05 and **P < 0.01 were considered statistically significantly different by the Tukey-Kramer test.