VCP inhibition induces an unfolded protein response and apoptosis in human acute myeloid leukemia cells
Fig 1
Inhibition of VCP leads to accumulation of ubiquitylated proteins and activates the unfolded protein response (UPR) in human acute myeloid leukemia (AML) cells.
Immunoblot showing poly-ubiquitylated proteins in THP-1 cells (A) and in a primary human AML long-term culture (FFM05) (B) after treatment with the VCP inhibitors CB-5083 or NMS-873 or the proteasome inhibitor MG-132. (C) Immunoblot showing expression of UPR-associated proteins in THP-1 and MV4-11 cells after treatment with 200 or 500 nM CB-5083 overnight.