P2X4 receptors mediate induction of antioxidants, fibrogenic cytokines and ECM transcripts; in presence of replicating HCV in in vitro setting: An insight into role of P2X4 in fibrosis
Fig 19
Schematic overview of the purinergic signaling in the presence of HCV.
HCV interrupts purinergic signaling Increased ATP in the extracellular mileu increases oxidative stress and fibrogenic cytokines and ECM cytokines leading towards fibrosis.