Brain-derived neurotrophic factor promotes immune reconstitution following radiation injury via activation of bone marrow mesenchymal stem cells
Fig 5
BDNF administration promotes thymic regeneration following TBI.
(A) Thymus weights at days 10 and 120 following irradiation and treatment with BDNF. (B) Representative day 120 thymi. (C) Total viable thymocytes at days 10 and 120. (D) Total numbers of double negative (DN), double positive (DP), CD4+ single positive, and CD8+ single positive cells at day 10. E, Total numbers of DN1, DN2, DN3, and DN4 thymocyte precursors at day 10. (Day 10: n = 5 mice per group). Shown are mean values + SEM. *P < .05, **P < .01, ****P < .0001.