Global Rhes knockout in the Q175 Huntington’s disease mouse model
Fig 5
MR Spectroscopy analysis of Q175/Rhes female mice, (A) at 6 months of age and (B) at 12 months of age, presenting measured striatal metabolite concentrations from: Ala, alanine; CHO, choline; CR+PCR, creatine+phosphocreatine; CR, creatine; GABA, gamma-aminobutyric acid; Glc, glucose; GLN, glutamine; GLU+GLN, glutamate+glutamine; GLU, glutamate; GPC, glycerophosphocholine; GSH, glutathione; INS, myo-inositol; NAA+NAAG, N-acetylaspartate+N-acetylaspartylglutamate; NAA, N-acetylaspartate; PCh, phosphocholine; PCr, phosphocreatine; TAU, taurine;. Data are presented as mean, + SEM (WT n = 9; RhesKO n = 11; Q175 n = 9; Q175;RhesKO n = 9); Two-way mixed ANODE followed by Tukey’s test, * p < 0.05.