Turnover rate of coenzyme A in mouse brain and liver
Fig 6
Half-life in male mouse brain of A) free CoA (CoASH) (+4 and+6 AMU), B) acetylCoA (+4 and +6 AMU) and C) total CoA +4 and +6 AMU. C57/Bl6 mice received an intrastriatal injection of 125 μg of +6 AMU labelled-fosmetpantotenate at each brain hemisphere (250 μg total dose) and brain samples were collected over a period of 336 h after dosing. For CoASH +4, acetylCoA +4 and total CoA +4 the time interval 96–336 h was considered for the half-life calculation. For CoASH +6, acetylCoA +6 and total CoA +6 the time interval 24–336 h was used and t = 48 h was excluded from the regression. Error bars, mean ± SD for triplicate samples.