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Turnover rate of coenzyme A in mouse brain and liver

Fig 3

Half-life of free CoA (CoASH) and acetylCoA in A) female B) male mouse liver. C57BL/6N mice were kept for 3 days under a PA-free diet and then orally dosed with 25 mg/kg of [¹³C₃-¹⁵N]-PA. Liver samples were collected and analysed by LC-HRMS to determine labelled (+4 AMU) and unlabelled CoASH and acetylCoA levels. The metabolite half-life was calculated from C_max to the last time point collected. Error bars, mean ± SD for triplicate samples.

doi: https://doi.org/10.1371/journal.pone.0251981.g003