Beneficial impact of cathelicidin on hypersensitivity pneumonitis treatment—In vivo studies
Fig 6
Changes in mouse pulmonary function in response to cathelicidin (CRAMP) and/or Saline Extract of Pantoea Agglomerans (SE-PA) treatment.
The frequency of breathing (f) and tidal volume (TV) was investigated before treatment and after every 7 days of mice exposure to investigated compounds. The data were collected every 2 s for 15 min. The data are presented as a mean of tested ventilatory parameters ± SEM. Each research group contained 8 mice: 6 treated and 2 untreated animals. A pulmonary function test was conducted in all animals. * p < 0.05 vs. untreated; ^ treated vs. untreated (comparison within corresponding time points); # p < 0.05 SE-PA+CRAMP vs. SE-PA (comparison within corresponding time points); @ p < 0.05 SE-PA 28 d. + CRAMP 14 d. vs. SE-PA 28 d. + untreated 14 d. (comparison within corresponding time points); $ p < 0.05 SE-PA 28 d. + CRAMP 14 d./ SE-PA 28 d. + untreated 14 d vs. SE-PA (day 28). One-way ANOVA test; Tuckey post-hoc test.