Larazotide acetate induces recovery of ischemia-injured porcine jejunum via repair of tight junctions
Fig 2
Histological examination of porcine jejunal mucosa subjected to ischemia and ex vivo recovery.
A: Unrecovered non-ischemic (uninjured) porcine jejunum. B: unrecovered ischemia-injured porcine jejunum. C: Recovered ischemia-injured porcine jejunum. D: Recovered ischemia-injured porcine jejunum treated with LA (1 μM). Ischemic injury resulted in the detachment of the epithelial monolayer from the basement membrane and sloughing of epithelium into the intestinal lumen (2B). After 4 hours of recovery, there were no histological differences between ischemia-injured jejunum treated with 1 μM LA (2D) versus untreated ischemia-injured jejunum (2C). Villous height appeared to be similar between groups, and no denuded surface was observed in either group. Hematoxylin and eosin stain, 100 μM scale bar.