Evaluation of the antiproliferative effects of the HASPIN inhibitor CHR-6494 in breast cancer cell lines
Fig 2
CHR-6494 inhibits the proliferation of breast cancer cells in vitro.
(A) Immunoblotting analysis of pH3T3. The breast cancer cells were treated with DMSO or CHR-6494 (1000 nM) for 24 h. The effects of CHR-6494 on the viability of MDA-MB-231 (B), MCF7 (C), SKBR3 (D), and MCF10A (E) cells were determined by XTT assay. IC50 values are shown for each cell line. Data are presented as the mean ± SD of three independent experiments.