Lack of collagen α6(IV) chain in mice does not cause severe-to-profound hearing loss or cochlear malformation, a distinct phenotype from nonsyndromic hearing loss with COL4A6 missense mutation
Fig 7
Distribution of major basement membrane components in the cochlea of WT and Col4a6 KO mice.
Cryosections were immunostained by antibodies against collagen α1(IV) chain (A, B), perlecan (C, D), laminin α1 (E, F), laminin α2 (G, H), laminin γ1 (I, J), and nidogen-1 (K, L). Nuclei were counterstained with Hoechst 33258 (blue). No differences are apparent between WT and Col4a6 KO mice. Scale bars = 50 μm.