Lack of collagen α6(IV) chain in mice does not cause severe-to-profound hearing loss or cochlear malformation, a distinct phenotype from nonsyndromic hearing loss with COL4A6 missense mutation
Fig 6
Representative images of HE-stained midmodiolar cochlear sections.
Histological comparison between WT (A, C, E) and Col4a6 KO (B, D, F) mice. (C-F) Images with higher magnification of cochlear basal turn are shown. No differences are observed between WT and Col4a6 KO mice. ⁎, basal turn; #, apical turn; SG, spiral ganglion; SLim, spiral limbus; TM, tectorial membrane; B, Basilar membrane; Co, organ of Corti; SLig, spiral ligament; SV, stria vascularis; RM, Reissner’s membrane; closed arrows, OHC (outer hair cells); arrows, IHC (inner hair cells); open arrowheads, Dieter’s cells.