Lack of collagen α6(IV) chain in mice does not cause severe-to-profound hearing loss or cochlear malformation, a distinct phenotype from nonsyndromic hearing loss with COL4A6 missense mutation
Fig 5
Comparison of the cochlea bone structure of WT and Col4a6 KO mice by micro-CT analysis.
(A) Representative three-dimensional images of the petrous portion of the left temporal bone in WT and Col4a6 KO mice. The top shows the apex of petrous in the superior view. (B–G) The three orthogonal plane images were automatically obtained as a best-matched plane from the Col4a6 KO data set compared to the images manually selected from the cochlea structure of the WT mice data set. (H–J) The overlay images demonstrated that no differences in the size or shape are apparent in the cochlear bone between WT and Col4a6 KO mice. Blue squares represent the Volume of Interest. (K) Light blue color indicates a highly matched degree based on the color map.