Lack of collagen α6(IV) chain in mice does not cause severe-to-profound hearing loss or cochlear malformation, a distinct phenotype from nonsyndromic hearing loss with COL4A6 missense mutation
Fig 4
Hearing threshold assessed by click-evoked auditory brainstem responses in WT and Col4a6 KO mice.
No significant difference observed between WT mice (mean 40 ± 3.5 dB SPL, n = 5) and Col4a6 KO mice (mean 43 ± 2.7 dB SPL, n = 5). P = 0.172 by Student’s unpaired t-tests. The values are presented as mean ± SD.