5-aminolaevulinic acid (5-ALA) accumulates in GIST-T1 cells and photodynamic diagnosis using 5-ALA identifies gastrointestinal stromal tumors (GISTs) in xenograft tumor models
Fig 5
5-ALA accumulation in GIST in vivo.
Flank tumor models were administered with 300 mg/kg 5-ALA via the tail vein. Four hours after 5-ALA administration, the spectral waveforms of normal skin tissue (blue line) and GIST (red line) were examined using a VLD-M1 spectrometer. A peak of fluorescence emission was observed at 635 nm, corresponding to PpIX.