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Physiologically based metformin pharmacokinetics model of mice and scale-up to humans for the estimation of concentrations in various tissues

Table 3

A comparison of metformin tissue-plasma partition coefficients in various mice tissues calculated using the method from Rogers et al. [14] and estimated in the model using parameter estimation, n.a.–data not available.

Table 3

doi: https://doi.org/10.1371/journal.pone.0249594.t003