Physiologically based metformin pharmacokinetics model of mice and scale-up to humans for the estimation of concentrations in various tissues
Fig 9
Schematic representation of a physiologically based pharmacokinetic model for metformin in mice and humans.
V–the reaction rate, S–the concentration of metformin at substrate side, P- the concentration of metformin at product side, Qblood−the flow to a particular compartment, Kt:p—tissue:plasma partition (Kt:p) coefficients, Kd—the non-saturable component of transport, Vmax—the maximal velocity, Km—the Michaelis-Menten constant. Red blood cells (RBC) compartment (dashed line) is used only in the human model.