Physiologically based metformin pharmacokinetics model of mice and scale-up to humans for the estimation of concentrations in various tissues
Fig 7
Metformin concentration time-courses in major compartments of metformin action.
Plasma (A), liver (B), kidney (C), intestine (D), muscle (E), brain (F), heart (G), adipose (H), stomach (I), lungs (J), the remainder (K), red blood cells (L)—following four PO doses of 500mg, 1000mg and 1500mg in humans at 0, 12, 24 and 36h in humans. The red lines represent the concentration-time profiles of the model simulations of the 500mg dose, the green lines represent model simulations for the 1000mg dose and the blue lines represent model simulations for the 1500mg dose.