Physiologically based metformin pharmacokinetics model of mice and scale-up to humans for the estimation of concentrations in various tissues
Fig 4
Metformin pharmacokinetics in plasma—model validation results for 250mg (A) [36], 500mg (B) [37], 750mg (C) [38] and 500mg (D) [39] PO doses in humans.
The red marks represent the experimental data’s concentration-time profiles from four different datasets, the error bars represent standard deviation, and the blue lines represent the model simulations.